Midwest Immunology Clinic

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    December 5, 2013  

" Intravenous Self-Administraion of C1-INH Concentrate for Hereditary Angioedema: A Retrospective Report of Real-World Experience on 13 Patients" 

Ralph Shapiro, MD

This paper was published by Dr. Ralph Shapiro in the The Journal of Angioedema,Vol 1, issue 2, 2013. This study was conducted to provide a retrospective view of treatment patterns, safety, and feasability of C1 esterase inhibitor (C1-INH) self administered at home under real world conditions. The concept of home management of hereditary angioedema (HAE) has been gaining favor in recent years and is recommended in recent HAE consensus guidelines.

This study was a retorspective review of longitudinal data gathered in routine follow-up of 13 patients with HAE who were traind to administer IV C1-INH concentrate at home, either as on-demand foracute attacks or as ongoing prophylaxis therapy.  Training in the sellf-administration of C1-INH conentrate is provided by highly trained clinic staff to the paitne and/or a parent, spouse or caregiver.

 This trial concluded that Self-administration of C1-INH as on-demand therapy or as a prophylaxis is a feasable strategy that can be used successfully to manage HAE.

Contratulations to Ralph Shapiro, MD on the publication of your study paper!!!


  1. Jeffrey Modell Foundation Opens Diagnostic Center for Primary Immunodeficiencies at Midwest Immunology Clinic 07-25-2012 PLYMOUTH, Minn., July 24, 2012 /PRNewswire/ --The Jeffrey Modell Foundation (JMF), in partnership with CSL Behring, has designated the Midwest Immunology Clinic in Plymouth, Minnesota as a Jeffrey Modell Diagnostic Center for Primary Immunodeficiencies (PI). The Center is headed by Ralph Shapiro, M.D. and is devoted to the diagnosis, treatment and care of people who have PI and autoimmune disorders. read more